Mechanisms Underlying Mood Disorders

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Cover image for research topic "Mechanisms Underlying Mood Disorders"
ChatGPT summary

Investigating the biological factors affecting mood disorders and their contributing environmental factors.

This research topic explores the association between peripheral arginine concentration, its catabolic products, major depressive disorder (MDD), and other factors such as gender, circadian dysregulation, theta-burst stimulation, Sinisan (SNS), the gut microbiota, M2-AChR, ketamine, the glymphatic system, nutrition, ventricular volumetric alterations, and BTX-A injections. Highlights of the findings include:

  • Concentrations of arginine, ornithine, and citrulline were not significantly different between individuals with MDD and healthy controls.
  • Gender differences in self-reporting symptoms of depression may lead to under-diagnosis and under-treatment of depression in males.
  • CLOCK gene variation interacts with childhood adversities and recent negative life events to influence lifetime depression and current depressive symptoms.
  • Intermittent theta-burst stimulation did not alter cognitive performance or concurrent prefrontal blood oxygenation in patients with treatment-resistant depression.
  • Sinisan reversed corticosterone-induced reduction of neuronal viability and prevented excessive autophagy through activation of PI3K/AKT/mTOR pathway.
  • Certain microbiota targets are associated with the severity of depression and sleep quality, and could potentially be used as biomarkers and/or treatment targets for sleep quality in MDD.
  • M2-AChR in the medial prefrontal cortex mediates the antidepressant-like effects of scopolamine by increasing the expression of BDNF and activating the mTORC1 signaling pathway.
  • Repeated dosing of ketamine has prominent depression-related effects that may help optimize its use in humans with Major Depressive Disorder.
  • The glymphatic system may be the bridge between sleep disturbance and mood disorders.
  • Nutritional interventions may be a complementary approach to medicating symptoms of anxiety disorders.
  • No significant differences in cognitive performance and ventricle volume were observed between euthymic and manic PBD groups.
  • BTX-A injections are associated with a statistically significant improvement in depressive symptoms and are generally safe and well
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