Mapping the Pathophysiology of Schizophrenia: Interactions Between Multiple Cellular Pathways, Volume II

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Editorial

16 June 2023

Editorial: Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways, volume II

Natalie Matosin

, 2 more and

Chao Deng

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Editors

4

University of Wollongong

Natalie Matosin

University of Wollongong

Jess Nithianantharajah

Florey Institute of Neuroscience and Mental Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne

Florey Institute of Neuroscience and Mental Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne

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ChatGPT summary

Investigating environmental-genetic interactions in schizophrenia development and etiology.

Research into the pathogenesis of schizophrenia has revealed a number of potential causes, including abnormalities in the GABA system, the adenosine hypothesis, and modulation of histone acetylation. Recent studies have also suggested that activating muscarinic M1 and M4 receptors, and miR-25-3p-mediated signaling pathways, may reduce the severity of schizophrenia symptoms. Cannabidiol (CBD) has potential to prevent schizophrenia development, although it may contribute to pathological changes in the brain. Finally, clozapine may act by normalizing perturbations in the glutamatergic signaling pathway.

This research topic has revealed a number of potential causes of schizophrenia, including:

Abnormalities in the GABA system
The adenosine hypothesis
Modulation of histone acetylation
Activating muscarinic M1 and M4 receptors
miR-25-3p-mediated signaling pathways
Cannabidiol (CBD)
Clozapine

These potential causes are being investigated to determine their contribution to the pathogenesis of schizophrenia, and to develop new treatments for the disorder.

The ChatGPT summary is generated out of the summaries of the individual article abstracts.

About

This is the second series for the Mapping the Pathophysiology of Schizophrenia: Interactions Between Multiple Cellular Pathways Research Topic. Schizophrenia is a complex disorder involving dysregulation of multiple CNS regions and processes in its pathophysiology. Whilst it has been long argued that dopaminergic, glutamatergic, GABAergic and cholinergic neurotransmitter systems are affected in schizophrenia, it is now clear that changes in gene expression in the CNS from patients with schizophrenia will have effects outside of these systems. In addition, it is also becoming clear that external stimuli such as stress and reactive processes such as inflammation, possibly during brain development and later in life, play major roles in the development and exacerbation of symptoms in schizophrenia. These complex cellular pathological processes are now recognised as being brought about because of interactions between disruptions in genetic and epigenetic mechanisms. This hypothesis is consistent with the pathology of schizophrenia being due to the inheritance of a genetic predisposition but with the onset frank symptomatology being triggered by environmental factors. Hence, this special issue will focus on the advancements made within the 10 years since the first Issue in this series on the pathophysiology of schizophrenia was published.

This is the second series for the Mapping the Pathophysiology of Schizophrenia: Interactions Between Multiple Cellular Pathways Research Topic. Schizophrenia is a complex disorder involving dysregulation of multiple CNS regions and processes in its pathophysiology. Whilst it has been long argued that dopaminergic, glutamatergic, GABAergic and cholinergic neurotransmitter systems are affected in schizophrenia, it is now clear that changes in gene expression in the CNS from patients with schizophrenia will have effects outside of these systems. In addition, it is also becoming clear that external stimuli such as stress and reactive processes such as inflammation, possibly during brain development and later in life, play major roles in the development and exacerbation of symptoms in schizophrenia. These complex cellular pathological processes are now recognised as being brought about because of interactions between disruptions in genetic and epigenetic mechanisms. This hypothesis is consistent with the pathology of schizophrenia being due to the inheritance of a genetic predisposition but with the onset frank symptomatology being triggered by environmental factors. Hence, this special issue will focus on the advancements made within the 10 years since the first Issue in this series on the pathophysiology of schizophrenia was published.

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Editors

University of Wollongong

Natalie Matosin

University of Wollongong

Jess Nithianantharajah

Florey Institute of Neuroscience and Mental Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne

Florey Institute of Neuroscience and Mental Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne

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15,918 Total views

11,758 Article views

3,538 Article downloads

622 Topic views

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Frontiers in Cellular Neuroscience

Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

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