Various kinds of hard and soft tissue injuries, such as bone fracture, cartilage damage, skin wound, and gastrointestinal injury are all in urgent need of wound closure and function restoration. Bio-adhesives are a perfect substitute of traditional sutures and staples due to their flexible compatibility with different wounds, noninvasive closure, degradation, and ease to remove. Both natural polymeric adhesives (collagen, alginate and fibrin) and synthetic polymers (polyethylene glycol, polyurethanes and cyanoacrylate adhesives) present promising platforms to accelerate the regeneration process. They have shown superiority in maintaining a moist environment, carrying living cells, and loading bioactive drugs or inorganic components. Consequent integrated therapy of wound closure, hemostasis, anti-inflammation and antibacterial activity are profitable for tissue remodeling. Bio-adhesives have also shown great potential in the application of in-situ tumor therapy after surgical resection and cosmetic treatment to reduce scar formation.
Although great success has been achieved in bio-adhesives, there are few products that can meet the requirements to bond firmly in bloody or moist environment, withstand the pressure of vessel or heart, adapt to the movement of skin, prevent leakage of contents, and degrade on-demand. Universal adhesives available for many different clinical applications are also rare. Thus, this Research Topic aims to attract the attention of more researchers and spread their latest progress on bioactive adhesives. Exploration and summarization including adhesives design, mechanisms study, clinical evaluation and various applications are all encouraged. Polymeric adhesives with great potential as bio-adhesives are also accessible, even though they have just been investigated in other fields instead of clinical application. Original research, short communication and review article are all welcome to present a comprehensive understanding of the recent advancements.
Topics include but not limited to:
1. Bio-mimetic tissue adhesives by mimicking the natural adhesion strategies of various animals and plants
2. Novel synthesized polymers, modification of polymer, or polymer-based hybrid biomaterials as adhesives
3. Many forms of bioactive adhesives, such as tapes, hydrogels, single or multi-component adhesives, and various engineering processes
4. Various polymeric medical adhesives and their applications in surgical wound closure, hemostasis, daily wound care, tissue adhesion, bone fracture fixation, and other chronic soft or hard wound regeneration (such as skin, viscera, cardiovascular, bone and teeth), as well as local drug delivery and in situ therapy
5. Potential application in the field of post-surgical cancer therapy and medical cosmetology
6. Combination of adhesives with bioactive ingredient available for antimicrobial and anti-inflammation application, neurologic repair, vascular regeneration, immunological regulation, cell differentiation and proliferation, metabolism regulation
7. Further and deeper mechanisms study of adhesives
8. Clinical applications report of polymeric adhesive biomaterials and their effectiveness evaluation
Various kinds of hard and soft tissue injuries, such as bone fracture, cartilage damage, skin wound, and gastrointestinal injury are all in urgent need of wound closure and function restoration. Bio-adhesives are a perfect substitute of traditional sutures and staples due to their flexible compatibility with different wounds, noninvasive closure, degradation, and ease to remove. Both natural polymeric adhesives (collagen, alginate and fibrin) and synthetic polymers (polyethylene glycol, polyurethanes and cyanoacrylate adhesives) present promising platforms to accelerate the regeneration process. They have shown superiority in maintaining a moist environment, carrying living cells, and loading bioactive drugs or inorganic components. Consequent integrated therapy of wound closure, hemostasis, anti-inflammation and antibacterial activity are profitable for tissue remodeling. Bio-adhesives have also shown great potential in the application of in-situ tumor therapy after surgical resection and cosmetic treatment to reduce scar formation.
Although great success has been achieved in bio-adhesives, there are few products that can meet the requirements to bond firmly in bloody or moist environment, withstand the pressure of vessel or heart, adapt to the movement of skin, prevent leakage of contents, and degrade on-demand. Universal adhesives available for many different clinical applications are also rare. Thus, this Research Topic aims to attract the attention of more researchers and spread their latest progress on bioactive adhesives. Exploration and summarization including adhesives design, mechanisms study, clinical evaluation and various applications are all encouraged. Polymeric adhesives with great potential as bio-adhesives are also accessible, even though they have just been investigated in other fields instead of clinical application. Original research, short communication and review article are all welcome to present a comprehensive understanding of the recent advancements.
Topics include but not limited to:
1. Bio-mimetic tissue adhesives by mimicking the natural adhesion strategies of various animals and plants
2. Novel synthesized polymers, modification of polymer, or polymer-based hybrid biomaterials as adhesives
3. Many forms of bioactive adhesives, such as tapes, hydrogels, single or multi-component adhesives, and various engineering processes
4. Various polymeric medical adhesives and their applications in surgical wound closure, hemostasis, daily wound care, tissue adhesion, bone fracture fixation, and other chronic soft or hard wound regeneration (such as skin, viscera, cardiovascular, bone and teeth), as well as local drug delivery and in situ therapy
5. Potential application in the field of post-surgical cancer therapy and medical cosmetology
6. Combination of adhesives with bioactive ingredient available for antimicrobial and anti-inflammation application, neurologic repair, vascular regeneration, immunological regulation, cell differentiation and proliferation, metabolism regulation
7. Further and deeper mechanisms study of adhesives
8. Clinical applications report of polymeric adhesive biomaterials and their effectiveness evaluation