Pro- and anti-geronic circulating factors are derived from organs like adipose tissue, the brain, the endocrine and immune system. It is increasingly understood that circulating pro-geronic factors, characterized by their increased production with age and their deleterious effects on tissue homeostasis, as well as the presence of anti-geronic factors, which reverse or prevent development of cellular aging phenotypes and presumably decline with age, orchestrate aging processes in various tissues.
Previous studies have characterized a range of anti-geronic circulating factors and attributed these to preventing or even rejuvenating aging phenotypes like cardiac hypertrophy, endothelial dysfunction, diminished skeletal muscle repair-efficiency, and reduced muscle strength. Pro-geronic factors appear to promote aging phenotypes such as decreased neurogenesis, vascular pathologies or cognitive dysfunction.
The current Research Topic seeks to facilitate understanding of the relative contribution of circulating factors to the genesis of aging phenotypes. We welcome submissions investigating the role of humoral factors in circulation including peptide, cytokines, circulating hormones and growth factors, and metabolites, and their regulation of cellular and molecular mechanisms of aging.
Pro- and anti-geronic circulating factors are derived from organs like adipose tissue, the brain, the endocrine and immune system. It is increasingly understood that circulating pro-geronic factors, characterized by their increased production with age and their deleterious effects on tissue homeostasis, as well as the presence of anti-geronic factors, which reverse or prevent development of cellular aging phenotypes and presumably decline with age, orchestrate aging processes in various tissues.
Previous studies have characterized a range of anti-geronic circulating factors and attributed these to preventing or even rejuvenating aging phenotypes like cardiac hypertrophy, endothelial dysfunction, diminished skeletal muscle repair-efficiency, and reduced muscle strength. Pro-geronic factors appear to promote aging phenotypes such as decreased neurogenesis, vascular pathologies or cognitive dysfunction.
The current Research Topic seeks to facilitate understanding of the relative contribution of circulating factors to the genesis of aging phenotypes. We welcome submissions investigating the role of humoral factors in circulation including peptide, cytokines, circulating hormones and growth factors, and metabolites, and their regulation of cellular and molecular mechanisms of aging.