We are honoured to present ‘GPCRs: Signal Transduction’ as part of the Frontiers in Molecular Biosciences GPCRs Research Topic Series.
GPCRs are comprised of 7 membrane-spanning domains and form one of the largest and most diverse families of membrane proteins, integral to an array of important signalling processes involved in regulating bodily functions, health and disease.
These cell-surface receptors detect a variety of extracellular signals, and subsequently interact with and activate associated G Proteins to stimulate downstream intracellular responses. These interactions are essential for a whole host of human functions, providing vital information and signals to the cell about the availability of essential resources and nutrients.
In light of the inherent role GPCRs play within the cell and human body as a whole, their function and dysfunction is often naturally involved in the pathways intrinsic in many diseases, and thus are an important drug and therapeutic target.
This Research Topic aims to bring together a community of like-minded field-experts, to help stimulate discussion and the sharing of ideas to fuel the scientific direction of future GPCR research within the field of Cellular Biochemistry. We invite submissions that contribute to the improvement of our collective understanding of the role GPCRs play in human health and disease, and welcome contributions covering all aspects of signalling transduction research in relation to GPCRs.
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Prof. Stuart Maudsley is a Co-Founder of private translational therapeutic GPCR company: HeptOME.
Dr. Lauren Slosky holds a patent relating to the composition and use of neurotensin receptor 1 ligands.
All other Topic Editors declare no conflict of interest.
We are honoured to present ‘GPCRs: Signal Transduction’ as part of the Frontiers in Molecular Biosciences GPCRs Research Topic Series.
GPCRs are comprised of 7 membrane-spanning domains and form one of the largest and most diverse families of membrane proteins, integral to an array of important signalling processes involved in regulating bodily functions, health and disease.
These cell-surface receptors detect a variety of extracellular signals, and subsequently interact with and activate associated G Proteins to stimulate downstream intracellular responses. These interactions are essential for a whole host of human functions, providing vital information and signals to the cell about the availability of essential resources and nutrients.
In light of the inherent role GPCRs play within the cell and human body as a whole, their function and dysfunction is often naturally involved in the pathways intrinsic in many diseases, and thus are an important drug and therapeutic target.
This Research Topic aims to bring together a community of like-minded field-experts, to help stimulate discussion and the sharing of ideas to fuel the scientific direction of future GPCR research within the field of Cellular Biochemistry. We invite submissions that contribute to the improvement of our collective understanding of the role GPCRs play in human health and disease, and welcome contributions covering all aspects of signalling transduction research in relation to GPCRs.
----------
Prof. Stuart Maudsley is a Co-Founder of private translational therapeutic GPCR company: HeptOME.
Dr. Lauren Slosky holds a patent relating to the composition and use of neurotensin receptor 1 ligands.
All other Topic Editors declare no conflict of interest.