Immunomodulatory Role of Metalloproteases in Chronic Inflammatory Diseases

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Exploring the immunoregulatory roles of metalloproteases in chronic inflammatory conditions

This research topic focuses on the role of metalloproteinases (MPs) and other proteins in various diseases, such as diabetes, colitis, IBD, asthma, and rheumatoid arthritis. It also explores the potential therapeutic implications of epigenetic modifications and natural products in these diseases.

  • Dendrobium officinale Kimura et Migo (D. officinale) has potential antioxidant capacity, anti-cyclooxygenase2 (COX-2) effect, anti-glycation potency, and anti-aging effects.
  • Matrix metalloproteases (MMPs) are involved in the healing process of diabetic ulcer and natural products have been shown to be potential therapeutic agents for diabetic ulcer therapy.
  • MMPs regulate intestinal inflammation and immunity mainly through CD8 in colitis.
  • ADAM28 expression by lung fibroblasts is linked to airway remodelling.
  • TET enzymes are important for decidualization and embryo implantation.
  • CD95L is a transmembrane ligand that has been associated with both apoptosis and non-apoptotic signals.
  • ADAM17 is a transmembrane protease involved in the shedding of cell membrane proteins and regulating various signaling pathways.
  • Herbal medicines have been found to inhibit the inflammatory process of RA by regulating MMPs and protecting joint structures.
  • HDAC1 plays a critical role in allergic response, stimulating expression in response to allergen and increasing Th2 cytokine levels.
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