Despite decades of experience taking care of pediatric patients in perioperative and critical care settings, a true definition of "hypotension" as it relates to organ perfusion remains elusive. A clear understanding of how changes in blood pressure affect organ perfusion, specifically in the setting of critical illness, sedation, and general anesthesia, is vital to ensuring good clinical outcomes. Additional knowledge in this area is needed to optimize perioperative and critical care in neonates, infants, and children of all ages.
This Research Topic will highlight the latest research investigating how anesthesia, sedation, and critical illness affect blood pressure, blood flow, and ultimately organ perfusion in neonates, infants, and children. Due to fundamental differences in vascular function that exist across the lifespan, this Research Topic seeks investigators who study premature neonates, term neonates, infants, and children. We are particularly interested in articles that help identify critical limits of hypotension (e.g., the blood pressure at which organ perfusion begins to decline) in different ages and under different conditions. Additional areas of interest would include determining the point at which organ hypoperfusion leads to irreversible damage, and prevention/treatment strategies.
Clinical and laboratory investigations as well as review articles are welcomed. Areas of particular interest:
-Age-related differences in blood pressure, vascular function, and organ perfusion (e.g., premature vs. neonate vs. infant vs. child)
-Research that helps define hypotension in an age and organ perfusion-specific manner
-Effects of anesthesia, sedation & critical illness on vascular function, organ perfusion, and outcomes
-Molecular/cellular mechanisms of differences in vascular function across childhood and how these mechanisms are altered by anesthesia and/or critical illness
-Autoregulation studies (in the brain and other organs)
-Studies that identify optimum treatment strategies (e.g., volume expansion, vasopressor therapy)
-Outcomes after hypotension/organ hypoperfusion
Despite decades of experience taking care of pediatric patients in perioperative and critical care settings, a true definition of "hypotension" as it relates to organ perfusion remains elusive. A clear understanding of how changes in blood pressure affect organ perfusion, specifically in the setting of critical illness, sedation, and general anesthesia, is vital to ensuring good clinical outcomes. Additional knowledge in this area is needed to optimize perioperative and critical care in neonates, infants, and children of all ages.
This Research Topic will highlight the latest research investigating how anesthesia, sedation, and critical illness affect blood pressure, blood flow, and ultimately organ perfusion in neonates, infants, and children. Due to fundamental differences in vascular function that exist across the lifespan, this Research Topic seeks investigators who study premature neonates, term neonates, infants, and children. We are particularly interested in articles that help identify critical limits of hypotension (e.g., the blood pressure at which organ perfusion begins to decline) in different ages and under different conditions. Additional areas of interest would include determining the point at which organ hypoperfusion leads to irreversible damage, and prevention/treatment strategies.
Clinical and laboratory investigations as well as review articles are welcomed. Areas of particular interest:
-Age-related differences in blood pressure, vascular function, and organ perfusion (e.g., premature vs. neonate vs. infant vs. child)
-Research that helps define hypotension in an age and organ perfusion-specific manner
-Effects of anesthesia, sedation & critical illness on vascular function, organ perfusion, and outcomes
-Molecular/cellular mechanisms of differences in vascular function across childhood and how these mechanisms are altered by anesthesia and/or critical illness
-Autoregulation studies (in the brain and other organs)
-Studies that identify optimum treatment strategies (e.g., volume expansion, vasopressor therapy)
-Outcomes after hypotension/organ hypoperfusion