Renal transplantation is a life-saving strategy for patients with end-stage renal disease that generally offers a favorable quality of life. However, immune-related post-transplant allograft dysfunctions have been demonstrated to be the principal reason for unfavorable short-term and long-term outcomes.
The immune system, which involves the complement system, immune cells, antibodies, and others, plays an important role in determining renal allograft survival. The immune system has been intimately associated with allograft rejection, which is the predominant cause of renal allograft failure. However, the underlying mechanisms of the abnormal activation of the immune system and subsequent allograft injury remain largely unknown. Further exploration of the underlying mechanisms for abnormal immune activation and allograft dysfunction holds the promise of uncovering potential therapeutic targets and extending renal allograft survival.
The purpose of this research topic is to explore the underlying mechanisms of the abnormality of the immune system in renal transplantation and investigate novel ways to regulate the immune system to improve renal allograft survival. We aim to collect manuscripts covering all aspects of the role of the immune system in renal transplantation, including but not limited to Original Research, Reviews, and Case Reports.
The submissions may refer to the following areas/topics:
1. Agents targeting the immune system for improving renal allograft survival;
2. Roles and mechanisms of immune systems in renal allograft dysfunction;
3. Anti-metabolites targeting cell metabolism to regulate the immune system in basic or preclinical or clinical trial studies;
4. Advances in immune system regulation technologies from both basic and clinical perspectives;
5. Clinical barriers and difficulties in the regulation of the immune system;
6. Any studies that explore the function of immune systems in renal transplantation are welcome.
Renal transplantation is a life-saving strategy for patients with end-stage renal disease that generally offers a favorable quality of life. However, immune-related post-transplant allograft dysfunctions have been demonstrated to be the principal reason for unfavorable short-term and long-term outcomes.
The immune system, which involves the complement system, immune cells, antibodies, and others, plays an important role in determining renal allograft survival. The immune system has been intimately associated with allograft rejection, which is the predominant cause of renal allograft failure. However, the underlying mechanisms of the abnormal activation of the immune system and subsequent allograft injury remain largely unknown. Further exploration of the underlying mechanisms for abnormal immune activation and allograft dysfunction holds the promise of uncovering potential therapeutic targets and extending renal allograft survival.
The purpose of this research topic is to explore the underlying mechanisms of the abnormality of the immune system in renal transplantation and investigate novel ways to regulate the immune system to improve renal allograft survival. We aim to collect manuscripts covering all aspects of the role of the immune system in renal transplantation, including but not limited to Original Research, Reviews, and Case Reports.
The submissions may refer to the following areas/topics:
1. Agents targeting the immune system for improving renal allograft survival;
2. Roles and mechanisms of immune systems in renal allograft dysfunction;
3. Anti-metabolites targeting cell metabolism to regulate the immune system in basic or preclinical or clinical trial studies;
4. Advances in immune system regulation technologies from both basic and clinical perspectives;
5. Clinical barriers and difficulties in the regulation of the immune system;
6. Any studies that explore the function of immune systems in renal transplantation are welcome.