Since April 2020, pediatric patients in Europe and the USA were reported presenting Kawasaki Disease-like shock syndrome. These patients showed pictures of variable severity up to multiorgan involvement and hyper inflammation, sometimes requiring intensive care. The CDC later defined this condition as Multisystem Inflammatory Syndrome in Children (MIS-C). The following diagnostic criteria were established: age <21 years; fever >24 hours; blood chemistry tests compatible with an inflammatory state; involvement of at least 2 organs or systems; severe clinical conditions requiring hospitalization; exclusion of other possible diagnoses, recent exposure (>4 weeks) to SARS-CoV-2 or positive nasopharyngeal swab or previous infection ascertained on serological examination. The immunopathogenesis of MIS-C is unclear but overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology has been described.
Given the recent onset of this entity, the severity of the disease and the need to start prompt effective therapy (knowing deeply immunological aspects of MIS-C, including cytokine, proteins, and cells involved) is crucial for more targeted therapeutic strategies. The aim of the Research Topic will be to collect the latest and recent advances in the pathogenesis of MIS-C
We are interested in original articles, case reports/series, and review of literature that describe particular aspects of disease
Since April 2020, pediatric patients in Europe and the USA were reported presenting Kawasaki Disease-like shock syndrome. These patients showed pictures of variable severity up to multiorgan involvement and hyper inflammation, sometimes requiring intensive care. The CDC later defined this condition as Multisystem Inflammatory Syndrome in Children (MIS-C). The following diagnostic criteria were established: age <21 years; fever >24 hours; blood chemistry tests compatible with an inflammatory state; involvement of at least 2 organs or systems; severe clinical conditions requiring hospitalization; exclusion of other possible diagnoses, recent exposure (>4 weeks) to SARS-CoV-2 or positive nasopharyngeal swab or previous infection ascertained on serological examination. The immunopathogenesis of MIS-C is unclear but overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology has been described.
Given the recent onset of this entity, the severity of the disease and the need to start prompt effective therapy (knowing deeply immunological aspects of MIS-C, including cytokine, proteins, and cells involved) is crucial for more targeted therapeutic strategies. The aim of the Research Topic will be to collect the latest and recent advances in the pathogenesis of MIS-C
We are interested in original articles, case reports/series, and review of literature that describe particular aspects of disease