Free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) can be generated in human body by various endogenous or exogenous sources, exposure to different pathological states or physiochemical conditions such as industrial solvents and radiation. Free radicals at low or moderate levels are vital to human health, involving their physiological roles in the function of many cellular signaling systems and acting as weapons for the host defence system. When free radicals overwhelm the body’s ability to regulate them, conditions known as oxidative stress and endoplasmic reticulum (ER) stress ensue. Excessive free radicals thus adversely alter the cell membranes and other structures such as proteins and DNA, triggering many diseases. Researchers have uncovered that antioxidants can act as “free radical scavengers” by preventing and repairing damages caused by ROS and RNS, lowering the risk of some diseases.
Immune and metabolic diseases like type 2 diabetes, neurodegenerative diseases, and cancer disorders are closely linked to an imbalance between free radical production and antioxidant defences. Therefore, it is necessary to clarify whether free radical is a target for therapeutic intervention in these diseases and further study the difference between organs and tissues, thereby providing new therapeutic strategies.
This Research Topic aims to cover recent advances in new insights into understanding the role of free radicals in immune and metabolic diseases and, more specifically, in the detection of new diagnostic and prognostic biomarkers. This topic will also highlight innovative therapeutic approaches to scavenge free radicals and their deleterious effects on immune, inflammatory, and metabolic diseases.
We welcome authors to submit original research articles as well as review articles that will stimulate the continuing efforts to understand the impact of free radical alterations on immune, inflammatory, and metabolic diseases. Potential topics are primary research articles and reviews covering the following subtopics, including but not limited to:
• New insights into an imbalance between formation and neutralization of ROS/RNS and how they can contribute to significant components of immune, inflammatory, and metabolic diseases;
• Novel diagnostic and prognostic biomarkers in immune, inflammatory, and metabolic diseases;
• Novel pharmacological and other therapy approaches in immune, inflammatory, and metabolic diseases;
• Review articles that summarize mechanistic knowledge, and current trends or highlight existing knowledge gaps and future directions for studying free radicals and antioxidants in immune, inflammatory, and metabolic diseases.
Free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) can be generated in human body by various endogenous or exogenous sources, exposure to different pathological states or physiochemical conditions such as industrial solvents and radiation. Free radicals at low or moderate levels are vital to human health, involving their physiological roles in the function of many cellular signaling systems and acting as weapons for the host defence system. When free radicals overwhelm the body’s ability to regulate them, conditions known as oxidative stress and endoplasmic reticulum (ER) stress ensue. Excessive free radicals thus adversely alter the cell membranes and other structures such as proteins and DNA, triggering many diseases. Researchers have uncovered that antioxidants can act as “free radical scavengers” by preventing and repairing damages caused by ROS and RNS, lowering the risk of some diseases.
Immune and metabolic diseases like type 2 diabetes, neurodegenerative diseases, and cancer disorders are closely linked to an imbalance between free radical production and antioxidant defences. Therefore, it is necessary to clarify whether free radical is a target for therapeutic intervention in these diseases and further study the difference between organs and tissues, thereby providing new therapeutic strategies.
This Research Topic aims to cover recent advances in new insights into understanding the role of free radicals in immune and metabolic diseases and, more specifically, in the detection of new diagnostic and prognostic biomarkers. This topic will also highlight innovative therapeutic approaches to scavenge free radicals and their deleterious effects on immune, inflammatory, and metabolic diseases.
We welcome authors to submit original research articles as well as review articles that will stimulate the continuing efforts to understand the impact of free radical alterations on immune, inflammatory, and metabolic diseases. Potential topics are primary research articles and reviews covering the following subtopics, including but not limited to:
• New insights into an imbalance between formation and neutralization of ROS/RNS and how they can contribute to significant components of immune, inflammatory, and metabolic diseases;
• Novel diagnostic and prognostic biomarkers in immune, inflammatory, and metabolic diseases;
• Novel pharmacological and other therapy approaches in immune, inflammatory, and metabolic diseases;
• Review articles that summarize mechanistic knowledge, and current trends or highlight existing knowledge gaps and future directions for studying free radicals and antioxidants in immune, inflammatory, and metabolic diseases.