Most of the eukaryotic genome is pervasively transcribed into RNA, however, only a few RNA can be translated into protein. A myriad of them do not possess protein coding abilities and are therefore defined as non-coding RNA. Non-coding RNA is classified according to its length, structure, and function into the following categories: long non-coding RNA (lncRNA, > 200nt), microRNA (miRNA), ribosomal RNA (rRNA), circular RNA (circRNA), etc. These were once regarded as “transcriptional noise”, but now non-coding RNAs has emerged as the key regulator in various biological processes such as XIST acting as a major effector of the inactivation of X-chromosome, and let-7 attending the developmental and aging process.Although some non-coding RNAs have been deciphered such as XIST and HOTAIR, the non-coding world is still largely unknown. In view of the emerging role of non-coding RNAs, this Research Topic aims to gather the findings on non-coding RNAs both in animals and plants to provide a comprehensive study set for the understanding of the non-coding RNA world. The advent of long- and short- read RNA sequencing, single-cell RNA sequencing, CRISPR, etc. has provided the high-efficiency tools required to unveil the non-coding RNA world. For example, single-cell RNA sequencing provides a high-throughput method to view the non-coding RNA in cell level and CRISPR dramatically boost the study of its function and mechanism.We welcome the submissions including Original Research, Methods, Protocols, Reviews, Reports and Perspectives in the following (but not limited to) sub-themes: 1. Genome-wide identification and functional profile of non-coding RNAs 2. Evolutionary analysis of non-coding RNAs by the comparative genomics (e.g., non-coding conservation, non-coding RNA origin, etc.) 3. Functional role of non-coding RNAs in disease, developmental processes, bio-/abiotic stress responses. 4. Molecular mechanisms of non-coding RNA regulation. 5. New method and tool to identify the non-coding RNAs and examine their functions.
Most of the eukaryotic genome is pervasively transcribed into RNA, however, only a few RNA can be translated into protein. A myriad of them do not possess protein coding abilities and are therefore defined as non-coding RNA. Non-coding RNA is classified according to its length, structure, and function into the following categories: long non-coding RNA (lncRNA, > 200nt), microRNA (miRNA), ribosomal RNA (rRNA), circular RNA (circRNA), etc. These were once regarded as “transcriptional noise”, but now non-coding RNAs has emerged as the key regulator in various biological processes such as XIST acting as a major effector of the inactivation of X-chromosome, and let-7 attending the developmental and aging process.Although some non-coding RNAs have been deciphered such as XIST and HOTAIR, the non-coding world is still largely unknown. In view of the emerging role of non-coding RNAs, this Research Topic aims to gather the findings on non-coding RNAs both in animals and plants to provide a comprehensive study set for the understanding of the non-coding RNA world. The advent of long- and short- read RNA sequencing, single-cell RNA sequencing, CRISPR, etc. has provided the high-efficiency tools required to unveil the non-coding RNA world. For example, single-cell RNA sequencing provides a high-throughput method to view the non-coding RNA in cell level and CRISPR dramatically boost the study of its function and mechanism.We welcome the submissions including Original Research, Methods, Protocols, Reviews, Reports and Perspectives in the following (but not limited to) sub-themes: 1. Genome-wide identification and functional profile of non-coding RNAs 2. Evolutionary analysis of non-coding RNAs by the comparative genomics (e.g., non-coding conservation, non-coding RNA origin, etc.) 3. Functional role of non-coding RNAs in disease, developmental processes, bio-/abiotic stress responses. 4. Molecular mechanisms of non-coding RNA regulation. 5. New method and tool to identify the non-coding RNAs and examine their functions.