The innate immune system is originally an important biological defense system of the hosts against various pathogens; however, it is occasionally pathogenic to the host in some sort of condition. The kidney is one of the targets of such attack by components of the innate immune system. Indeed, roles for the components of the innate immune system such as monocyte/macrophages, polymorphonuclear leukocytes, NK/NKT cells, and activation of the complement system have been reported in the development of acute kidney injury (AKI) and chronic kidney diseases (CKD) of various causes, such as diabetic kidney disease (DKD), acute/chronic glomerulonephritis, tubulointerstitial nephritis, renal vasculitis, thrombotic microangiopathy (TMA), and kidney transplant rejection.
Recent advances in the field of molecular targeted drug therapy have enabled to establish a novel therapeutic option according to the pathogenic target of diseases. Considering the nature of the innate immune system, they would play their role in the early phase of the disease process. Because the target of the earlier disease phase would be more effective than the target of the later disease phase, understanding the pathogenic aspects of the innate immune system as the therapeutic target of kidney injury is very important.
In this Research Topic, we welcome case reports, original research, and review articles in the field, with a focus on but not limited to the roles of the components of the innate immune system on kidney injury, such as AKI of various causes, CKD due to DKD, glomerulonephritis, tubulointerstitial nephritis, renal vasculitis, TMA, and kidney transplant rejection.
The innate immune system is originally an important biological defense system of the hosts against various pathogens; however, it is occasionally pathogenic to the host in some sort of condition. The kidney is one of the targets of such attack by components of the innate immune system. Indeed, roles for the components of the innate immune system such as monocyte/macrophages, polymorphonuclear leukocytes, NK/NKT cells, and activation of the complement system have been reported in the development of acute kidney injury (AKI) and chronic kidney diseases (CKD) of various causes, such as diabetic kidney disease (DKD), acute/chronic glomerulonephritis, tubulointerstitial nephritis, renal vasculitis, thrombotic microangiopathy (TMA), and kidney transplant rejection.
Recent advances in the field of molecular targeted drug therapy have enabled to establish a novel therapeutic option according to the pathogenic target of diseases. Considering the nature of the innate immune system, they would play their role in the early phase of the disease process. Because the target of the earlier disease phase would be more effective than the target of the later disease phase, understanding the pathogenic aspects of the innate immune system as the therapeutic target of kidney injury is very important.
In this Research Topic, we welcome case reports, original research, and review articles in the field, with a focus on but not limited to the roles of the components of the innate immune system on kidney injury, such as AKI of various causes, CKD due to DKD, glomerulonephritis, tubulointerstitial nephritis, renal vasculitis, TMA, and kidney transplant rejection.