Primary liver cancer (PLC), including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), and other rare tumors, is the third leading cause of cancer-related mortality. Of all primary liver cancer, HCC is the most common type. Evidence has accumulated that the tumor microenvironment (TME) plays a key role in fostering or restraining tumor development. The tumor microenvironment (TME), which includes molecular, cellular, extracellular matrix(ECM), and vascular signaling pathways, is a complex ecosystem. The interaction between the tumor microenvironment and cancer cells can enhance the malignant properties of tumors, including proliferation, angiogenesis, metastasis, and therapy resistance. In addition, the tumor microenvironment can also lead to abnormal angiogenesis and promote immunosuppression. HCC has been resistant to targeted therapy and immunotherapy. Therefore, further study of the tumor microenvironment of HCC may be helpful for the development of therapeutic methods for HCC.
The tumor microenvironment in hepatocellular carcinoma is quite different from that in other tumors. Recent studies have provided new insight into the molecular mechanisms of the generation and progression of tumor microenvironment in hepatocellular carcinoma. Metabolic reprogramming of tumor microenvironment has been shown to play an important role in drug resistance of hepatocellular carcinoma. However, much about the tumor microenvironment in hepatocellular carcinoma progression remains unknown.
This Research Topic will focus on the emerging findings about the role and mechanism of tumor microenvironment in hepatocellular carcinoma development, treatment, and prognosis. This Research Topic welcomes submissions of Original Research and Review focusing on but not limited to:
• The role of tumor immune microenvironment in the development, treatment and prognosis of hepatocellular carcinoma.
• The role of tumor metabolic microenvironment in the development, treatment and prognosis of hepatocellular carcinoma.
• The role of tumor-associated genes microenvironment in the development, treatment and prognosis of hepatocellular carcinoma.
• The role of gut microbial microenvironment in the development, treatment and prognosis of hepatocellular carcinoma.
• Crosstalk and interaction among hepatocellular carcinoma genes microenvironment, immune microenvironment, metabolic microenvironment, and gut microbial microenvironment.
• Potential therapeutic targets of hepatocellular carcinoma via modulating tumor genes microenvironment, immune microenvironment, metabolic microenvironment, and gut microbial microenvironment.
Primary liver cancer (PLC), including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), and other rare tumors, is the third leading cause of cancer-related mortality. Of all primary liver cancer, HCC is the most common type. Evidence has accumulated that the tumor microenvironment (TME) plays a key role in fostering or restraining tumor development. The tumor microenvironment (TME), which includes molecular, cellular, extracellular matrix(ECM), and vascular signaling pathways, is a complex ecosystem. The interaction between the tumor microenvironment and cancer cells can enhance the malignant properties of tumors, including proliferation, angiogenesis, metastasis, and therapy resistance. In addition, the tumor microenvironment can also lead to abnormal angiogenesis and promote immunosuppression. HCC has been resistant to targeted therapy and immunotherapy. Therefore, further study of the tumor microenvironment of HCC may be helpful for the development of therapeutic methods for HCC.
The tumor microenvironment in hepatocellular carcinoma is quite different from that in other tumors. Recent studies have provided new insight into the molecular mechanisms of the generation and progression of tumor microenvironment in hepatocellular carcinoma. Metabolic reprogramming of tumor microenvironment has been shown to play an important role in drug resistance of hepatocellular carcinoma. However, much about the tumor microenvironment in hepatocellular carcinoma progression remains unknown.
This Research Topic will focus on the emerging findings about the role and mechanism of tumor microenvironment in hepatocellular carcinoma development, treatment, and prognosis. This Research Topic welcomes submissions of Original Research and Review focusing on but not limited to:
• The role of tumor immune microenvironment in the development, treatment and prognosis of hepatocellular carcinoma.
• The role of tumor metabolic microenvironment in the development, treatment and prognosis of hepatocellular carcinoma.
• The role of tumor-associated genes microenvironment in the development, treatment and prognosis of hepatocellular carcinoma.
• The role of gut microbial microenvironment in the development, treatment and prognosis of hepatocellular carcinoma.
• Crosstalk and interaction among hepatocellular carcinoma genes microenvironment, immune microenvironment, metabolic microenvironment, and gut microbial microenvironment.
• Potential therapeutic targets of hepatocellular carcinoma via modulating tumor genes microenvironment, immune microenvironment, metabolic microenvironment, and gut microbial microenvironment.