Plant-derived bioactive metabolites can now be investigated analytically using ever advanced chromatographic methods like HPTLC, HPLC, LCMS/MS, which are also essential to isolate and characterize the potentially bioactive metabolites.
Dereplication plays an important role avoiding the isolation of known metabolites or those which have non-specific effects, since it quickly identifies metabolites that are present in complicated mixtures, avoiding time-consuming isolation methods.
Such metabolites have attracted more attention in recent days due to their significant advantages in the prevention and management of metabolic syndrome, including obesity, diabetes, and cardiovascular illnesses.
A metabolic syndrome is a group of illnesses that co-occur and raise the risk of heart disease, stroke, and type 2 diabetes linked to excessive blood pressure, extra body fat around the waist, and abnormal cholesterol or triglyceride levels.
Despite substantial progress in recent years in understanding the mechanisms underlying the health benefits of bioactive natural products, there hasn't been much success in treating a number of serious illnesses like cardiovascular disease, diabetes, and obesity.
Ultimately such interventions enhance patient well-being and lessen the burden of obesity, diabetes, and cardiovascular illnesses worldwide.
The goal of this research topic is to build a novel, up-to-date corpus of information about the role of isolated bioactive metabolites and of chemically well-characterised extracts from plants (and fungi) in controlling and preventing metabolic syndrome.
Authors are invited to contribute original articles and reviews including but not limited to the following topics:
1. Isolation, and characterization of bioactive metabolites from medicinal plants using different analytical techniques like HPLC, LCMS/MS, NMR.
2. Clinical investigations of isolated metabolites in the treatment of disorders associated with metabolic syndrome like cardiovascular, diabetes, obesity.
3. Experimental pharmacological studies of bioactive metabolites using in-vitro and in-vivo approaches and pharmacokinetic studies on bioactive metabolites.
4. Novel approaches to the application of phytomedicines in cardiovascular disorders.
5. Recent ethnopharmacological advances in the diagnosis, treatment, and prevention of cardiovascular, diabetes, and obesity diseases and disorders including studies on the uses of plants for these diseases.
In general such experimental studies must be based on local and traditional uses of the species investigated and this must be documented using primary literature.
All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here
). Specifically, please note the need to phytochemically characterise the preparations used in detail (see The ConPhyMP-Guidelines