According to the American Cancer Society, colorectal cancer is the third most common cancer in the United States. It has been estimated that in 2022 in the US, 106.180 and 44.850 new cases of colon and rectal cancer occurred, respectively.
Overall, colorectal cancer is the third leading cause of cancer-related deaths in the United States. However, the death rate for colorectal cancer has been dropping in the last decades. One of the main reasons for these results is the introduction of screening programs and the improvement of the treatment protocols including chemotherapy, radiotherapy, and surgery.
Despite these encouraging results, colorectal cancers are still responsible for local recurrence and distant metastases. These conditions significantly worsen patients’ overall survival and disease-free survival. However, also for the treatment of these advanced stages a great effort has been done in the last years to improve the survival.
The aim of this Research Topic is to report the most recent treatment protocols for the treatment of local recurrence and distant metastases from colorectal cancer.
Themes of interest include, but are not limited to, the following:
• The role of endoscopy in the treatment of colorectal local recurrence.
• Surgical treatment of pelvic colorectal metastases.
• Surgical treatment of peritoneal carcinomatosis from colorectal cancer.
• New chemotherapy protocol for the treatment of colorectal liver metastases.
• Radiological treatment of colorectal liver metastases.
• Surgical treatment of colorectal liver metastases.
• New chemotherapy protocol for the treatment of colorectal lung metastases.
• Surgical treatment of colorectal thoracic metastases.
• The role of radiotherapy.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
According to the American Cancer Society, colorectal cancer is the third most common cancer in the United States. It has been estimated that in 2022 in the US, 106.180 and 44.850 new cases of colon and rectal cancer occurred, respectively.
Overall, colorectal cancer is the third leading cause of cancer-related deaths in the United States. However, the death rate for colorectal cancer has been dropping in the last decades. One of the main reasons for these results is the introduction of screening programs and the improvement of the treatment protocols including chemotherapy, radiotherapy, and surgery.
Despite these encouraging results, colorectal cancers are still responsible for local recurrence and distant metastases. These conditions significantly worsen patients’ overall survival and disease-free survival. However, also for the treatment of these advanced stages a great effort has been done in the last years to improve the survival.
The aim of this Research Topic is to report the most recent treatment protocols for the treatment of local recurrence and distant metastases from colorectal cancer.
Themes of interest include, but are not limited to, the following:
• The role of endoscopy in the treatment of colorectal local recurrence.
• Surgical treatment of pelvic colorectal metastases.
• Surgical treatment of peritoneal carcinomatosis from colorectal cancer.
• New chemotherapy protocol for the treatment of colorectal liver metastases.
• Radiological treatment of colorectal liver metastases.
• Surgical treatment of colorectal liver metastases.
• New chemotherapy protocol for the treatment of colorectal lung metastases.
• Surgical treatment of colorectal thoracic metastases.
• The role of radiotherapy.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.