Alcohol consumption has been a part of human culture throughout the ages. Moderate alcohol consumption may have some beneficial effects on host health, but alcohol abuse (both short-term and long-term) can have negative effects that include acute alcoholism in the short term or diseases resulting from long-term alcohol accumulation, such as gastrointestinal and liver diseases, neuropsychiatric disorders, and various types of cancer. Currently, abstinence from alcohol is still the most effective and important therapy for alcohol-related diseases; nevertheless, there is an urgent need for research to develop effective treatment programs related to alcoholism. As the largest endocrine organ in the body, the intestinal flora could interact with the digestive, endocrine, immune and nervous systems of the host to maintain homeostasis. And the close crosstalk that occurs by altering the balance between the host's endocrine system and the intestinal flora could drive the development of alcohol-related diseases. Therefore, clarifying the interactions between the gut flora and the endocrine system in alcohol-related diseases and their cause-and-effect relationships is essential.The Research Topic aims to clarify the interactions between gut microbes and the endocrine system in alcohol-related diseases and their causal relationships. It can contribute to discovering the pathogenesis of alcohol-related diseases and the development of treatment options for these diseases to improve public health and quality of life.Potential sub-topics include but are not limited to:• Based on the theory of gut-liver axis, to explore the interaction of intestinal flora and metabolites with alcoholic liver injury, intestinal and liver immune regulation, and liver endocrine homeostasis;• Focusing on the theory of gut-brain axis, to explore the interactions between gut flora and its related metabolites and alcoholic neurological disorders, neuroimmune regulation and neuroendocrine homeostasis;• Focusing on the gut-liver and gut-brain axis, to carry out microbiota transplantation, drugs, microecological agents and dietary interventions for alcohol-related diseases, exploring therapeutic strategies for these diseases based on the regulation of endocrine system homeostasis by gut microbiota and metabolites;• To explore the pathogenesis and treatment strategy of alcoholic hepatic encephalopathy based on the interaction between intestinal microbes and the endocrine system in alcohol-related diseases.
Alcohol consumption has been a part of human culture throughout the ages. Moderate alcohol consumption may have some beneficial effects on host health, but alcohol abuse (both short-term and long-term) can have negative effects that include acute alcoholism in the short term or diseases resulting from long-term alcohol accumulation, such as gastrointestinal and liver diseases, neuropsychiatric disorders, and various types of cancer. Currently, abstinence from alcohol is still the most effective and important therapy for alcohol-related diseases; nevertheless, there is an urgent need for research to develop effective treatment programs related to alcoholism. As the largest endocrine organ in the body, the intestinal flora could interact with the digestive, endocrine, immune and nervous systems of the host to maintain homeostasis. And the close crosstalk that occurs by altering the balance between the host's endocrine system and the intestinal flora could drive the development of alcohol-related diseases. Therefore, clarifying the interactions between the gut flora and the endocrine system in alcohol-related diseases and their cause-and-effect relationships is essential.The Research Topic aims to clarify the interactions between gut microbes and the endocrine system in alcohol-related diseases and their causal relationships. It can contribute to discovering the pathogenesis of alcohol-related diseases and the development of treatment options for these diseases to improve public health and quality of life.Potential sub-topics include but are not limited to:• Based on the theory of gut-liver axis, to explore the interaction of intestinal flora and metabolites with alcoholic liver injury, intestinal and liver immune regulation, and liver endocrine homeostasis;• Focusing on the theory of gut-brain axis, to explore the interactions between gut flora and its related metabolites and alcoholic neurological disorders, neuroimmune regulation and neuroendocrine homeostasis;• Focusing on the gut-liver and gut-brain axis, to carry out microbiota transplantation, drugs, microecological agents and dietary interventions for alcohol-related diseases, exploring therapeutic strategies for these diseases based on the regulation of endocrine system homeostasis by gut microbiota and metabolites;• To explore the pathogenesis and treatment strategy of alcoholic hepatic encephalopathy based on the interaction between intestinal microbes and the endocrine system in alcohol-related diseases.