Contemporary sedentary lifestyles, eating habits, and increased survival after a cardiovascular event have caused the prevalence of other chronic diseases to grow exponentially. Heart failure, type 2 diabetes mellitus, often associated with obesity, fatty liver disease, and its complications, and chronic kidney disease are the major health problems we will face in the 21st century. These conditions often coexist, are underdiagnosed, and represent a very high cost to the healthcare system. This is exacerbated because their coexistence worsens the patient's prognosis. However, they are also conditions that, if diagnosed on time, can be treated, interrupting their natural course. This has led to the rise of management in multidisciplinary units, which has become evident with the dawn of the concept of the cardio-renal-metabolic syndrome and is even more reinforced because of the development of drugs with multitarget and pleiotropic effects.This Research Topic aims to broaden the knowledge of cardio-renal-metabolic syndrome to better understand this interconnection from a broad view in terms of both practical reviews on multimodal approaches and translational and clinical new research with an emphasis on improving the care of patients. This Research Topic may fulfill knowledge on any topic and from any methodological path. It may include practical approaches to the whole syndrome or subtopics in special populations, systematic or other kinds of reviews that may collect the actual knowledge and raise new hypotheses, and original research, whether clinical, translational, or basic science. Papers should focus on (but are not limited to):- chronic kidney disease (CKD), heart failure (HF), or cardiorenal syndromes- cardiovascular disease (CVD) in CKD and the role of chronic kidney disease - mineral and bone disorder (CKD-MBD) in CVD- diabetes, obesity, and its role in both CVD and CKD- the emergence of non-alcoholic fatty liver disease (NAFLD) as a cofactor in CKD
Contemporary sedentary lifestyles, eating habits, and increased survival after a cardiovascular event have caused the prevalence of other chronic diseases to grow exponentially. Heart failure, type 2 diabetes mellitus, often associated with obesity, fatty liver disease, and its complications, and chronic kidney disease are the major health problems we will face in the 21st century. These conditions often coexist, are underdiagnosed, and represent a very high cost to the healthcare system. This is exacerbated because their coexistence worsens the patient's prognosis. However, they are also conditions that, if diagnosed on time, can be treated, interrupting their natural course. This has led to the rise of management in multidisciplinary units, which has become evident with the dawn of the concept of the cardio-renal-metabolic syndrome and is even more reinforced because of the development of drugs with multitarget and pleiotropic effects.This Research Topic aims to broaden the knowledge of cardio-renal-metabolic syndrome to better understand this interconnection from a broad view in terms of both practical reviews on multimodal approaches and translational and clinical new research with an emphasis on improving the care of patients. This Research Topic may fulfill knowledge on any topic and from any methodological path. It may include practical approaches to the whole syndrome or subtopics in special populations, systematic or other kinds of reviews that may collect the actual knowledge and raise new hypotheses, and original research, whether clinical, translational, or basic science. Papers should focus on (but are not limited to):- chronic kidney disease (CKD), heart failure (HF), or cardiorenal syndromes- cardiovascular disease (CVD) in CKD and the role of chronic kidney disease - mineral and bone disorder (CKD-MBD) in CVD- diabetes, obesity, and its role in both CVD and CKD- the emergence of non-alcoholic fatty liver disease (NAFLD) as a cofactor in CKD