Intestinal immune function accounts for about 70% of the systemic immune function. As the intestinal tract is the body's largest immune organ, it becomes the body's front line of defense. While intestinal mucosal injury leads to intestinal immune dysfunction and immune cell metabolic disorder.
Taking nutrients from daily diets is an effective way to improve intestinal immunity. Various nutrients, such as functional polysaccharides, peptides, nucleotides, oligosaccharides, probiotics, and polyphenols have been recently shown to affect the metabolism of immune cells, by directly stimulating antigen-presenting cells after being transferred by special intestinal cells to Payer's patches or MLNs, or indirectly regulated by changing the immune microenvironment, and finally, they shift the fate of immune responses. The regulation and repair effects of these nutrients are closely related to the immunometabolism of immune cells. For example, mannose can suppress TNF-α production in macrophages by changing the level of intermediate products of glycolysis. Therefore, understanding the potential effects of special nutrients and immunometabolism on intestinal mucosal immunity will provide more novel strategies to promote the application of nutritional immunology and the study of its mechanism.
The goal of this Research Topic is to provide a communication forum to advance research on the immunometabolism of intestinal mucosal immunity with its nutritional regulation, in an attempt to achieve beneficial impacts on the injured intestinal mucosa. We aim to provide more novel strategies to promote the application of nutritional immunology and the study of its mechanism, and to find new functional metabolites with immunomodulatory activities with synthetic biotechnology.
The submissions of Original Research and Review articles are welcome including but not limited to the following subtopics:
1. Immunomodulatory effects of functional nutrients based on the innovation of methods or technologies with in vitro and in vivo models;
2. Effects of immunometabolism of immune cells on the treatment of injured intestinal mucosa;
3. Effects of functional nutrients on immunometabolism of intestinal mucosal immunity;
4. Determination of target immune cells or molecules of nutritional immunology;
5. Crosstalk of gut microbiota as the immune microenvironment of immunometabolism, with reproductive organs, immune organs, and metabolic organs;
6. Molecular mechanisms and signaling pathways on immunometabolism of intestinal mucosal immune cells with its regulation by functional polysaccharides, peptides, nucleotide, polyphenols, oligosaccharides, or probiotics;
7. Utilization of synthetic biotechnology to find new functional metabolites and evaluation of nutritional regulation on molecules with immunomodulatory activities.
Intestinal immune function accounts for about 70% of the systemic immune function. As the intestinal tract is the body's largest immune organ, it becomes the body's front line of defense. While intestinal mucosal injury leads to intestinal immune dysfunction and immune cell metabolic disorder.
Taking nutrients from daily diets is an effective way to improve intestinal immunity. Various nutrients, such as functional polysaccharides, peptides, nucleotides, oligosaccharides, probiotics, and polyphenols have been recently shown to affect the metabolism of immune cells, by directly stimulating antigen-presenting cells after being transferred by special intestinal cells to Payer's patches or MLNs, or indirectly regulated by changing the immune microenvironment, and finally, they shift the fate of immune responses. The regulation and repair effects of these nutrients are closely related to the immunometabolism of immune cells. For example, mannose can suppress TNF-α production in macrophages by changing the level of intermediate products of glycolysis. Therefore, understanding the potential effects of special nutrients and immunometabolism on intestinal mucosal immunity will provide more novel strategies to promote the application of nutritional immunology and the study of its mechanism.
The goal of this Research Topic is to provide a communication forum to advance research on the immunometabolism of intestinal mucosal immunity with its nutritional regulation, in an attempt to achieve beneficial impacts on the injured intestinal mucosa. We aim to provide more novel strategies to promote the application of nutritional immunology and the study of its mechanism, and to find new functional metabolites with immunomodulatory activities with synthetic biotechnology.
The submissions of Original Research and Review articles are welcome including but not limited to the following subtopics:
1. Immunomodulatory effects of functional nutrients based on the innovation of methods or technologies with in vitro and in vivo models;
2. Effects of immunometabolism of immune cells on the treatment of injured intestinal mucosa;
3. Effects of functional nutrients on immunometabolism of intestinal mucosal immunity;
4. Determination of target immune cells or molecules of nutritional immunology;
5. Crosstalk of gut microbiota as the immune microenvironment of immunometabolism, with reproductive organs, immune organs, and metabolic organs;
6. Molecular mechanisms and signaling pathways on immunometabolism of intestinal mucosal immune cells with its regulation by functional polysaccharides, peptides, nucleotide, polyphenols, oligosaccharides, or probiotics;
7. Utilization of synthetic biotechnology to find new functional metabolites and evaluation of nutritional regulation on molecules with immunomodulatory activities.