Renal transplantation considerably increases patient life expectancy and quality of life compared to dialysis, it is regarded as the gold therapeutic strategy for patients with end-stage renal disease. In addition to the survival rate in transplant patients, allograft failure is a significant source of worry since graft loss raises mortality and can add pressure to a community healthcare system. Age, race, gender and immunologic compatibility of the recipient and donor are preoperative variables that affect function of graft and its survival. Additionally, a number of post-operative factors, including post-operative immunosuppressive therapy and the duration of cold and warm ischemia, have an impact on graft function and rejection. However, in contrast to short-term survival rates, long-term graft survival has not met recovery expectations despite successful kidney transplant surgery. But following transplantation, post-transplant patients typically experience post-transplant cardiovascular and cardiovascular-related mortality. Acute rejection must be avoided for a kidney transplant to be successful, and novel immunosuppressive therapies significantly enhance transplant survival by lowering the frequency of acute rejection. Analyzing kidney transplant data can help determine how effective transplantation efforts are as well as how much the future health care system will cost. The aim and objective of this Research Topic is to discuss the physiological and molecular aspects that affect post-operative graft rejection and general quality of life. In order to improve patient survival, this article collection intends to bring together physician experts in renal transplant treatment and basic researchers working in the field of nephrology/renal replacement therapy on either human or pre-clinical models.In addition to original research articles, opinions, and methods pertinent to this article collection, researchers are encouraged to submit theoretical papers, pharmacological intervention studies, reviews, mini-reviews, perspectives, and short communications. These articles should cover topics like (but are not limited to):• Factors need to consider before renal transplant (ae: patients comorbidities, HLA matching)• Management of blood pressure after renal transplant• Post-transplant care• Psychological and psychophysiological aspects of kidney transplant• Pregnancy outcome after transplant• Graft from deceased vs living donor• Multi organ transplant along with renal transplant.• Post-transplant recovery• Pharmacological effects of post-transplant kidney patient.• Non immunological complications following transplant.
Renal transplantation considerably increases patient life expectancy and quality of life compared to dialysis, it is regarded as the gold therapeutic strategy for patients with end-stage renal disease. In addition to the survival rate in transplant patients, allograft failure is a significant source of worry since graft loss raises mortality and can add pressure to a community healthcare system. Age, race, gender and immunologic compatibility of the recipient and donor are preoperative variables that affect function of graft and its survival. Additionally, a number of post-operative factors, including post-operative immunosuppressive therapy and the duration of cold and warm ischemia, have an impact on graft function and rejection. However, in contrast to short-term survival rates, long-term graft survival has not met recovery expectations despite successful kidney transplant surgery. But following transplantation, post-transplant patients typically experience post-transplant cardiovascular and cardiovascular-related mortality. Acute rejection must be avoided for a kidney transplant to be successful, and novel immunosuppressive therapies significantly enhance transplant survival by lowering the frequency of acute rejection. Analyzing kidney transplant data can help determine how effective transplantation efforts are as well as how much the future health care system will cost. The aim and objective of this Research Topic is to discuss the physiological and molecular aspects that affect post-operative graft rejection and general quality of life. In order to improve patient survival, this article collection intends to bring together physician experts in renal transplant treatment and basic researchers working in the field of nephrology/renal replacement therapy on either human or pre-clinical models.In addition to original research articles, opinions, and methods pertinent to this article collection, researchers are encouraged to submit theoretical papers, pharmacological intervention studies, reviews, mini-reviews, perspectives, and short communications. These articles should cover topics like (but are not limited to):• Factors need to consider before renal transplant (ae: patients comorbidities, HLA matching)• Management of blood pressure after renal transplant• Post-transplant care• Psychological and psychophysiological aspects of kidney transplant• Pregnancy outcome after transplant• Graft from deceased vs living donor• Multi organ transplant along with renal transplant.• Post-transplant recovery• Pharmacological effects of post-transplant kidney patient.• Non immunological complications following transplant.