This Research Topic is part of a series with:
Novel Targets for Chronic Inflammatory Diseases: Focus On Therapeutic Drugs and Natural Compounds
Chronic inflammation is a component of many disease conditions that affect a large group of individuals worldwide, which is characterized by persistent, low-grade inflammation and is increased in the aging population. It occurs when an initiating stimulus is not removed or if the resolution process is disrupted, resulting in a state of low-grade inflammation. It is acknowledged that chronic inflammatory diseases are involved in cardiovascular diseases, endocrine disease, neurodegenerative disease, hepatic disease, pulmonary disease, gastrointestinal disease, and cancer et al., including but not limited to atherosclerosis, diabetes, multiple sclerosis, fibrosis, NAFLD, COPD, inflammatory bowel disease, autoimmune disorders(like SLE, RA), which are major causes of death worldwide. Immunity is a physiological function of the human body, which maintains health by destroying and rejecting foreign substances including antigens, damaged cells, and tumors et al. There is a close relationship between inflammation and immunity, whether they are both protective mechanisms against invasion or injury responses. Therefore, the important role of inflammatory and immune responses should be noted, it is necessary to explore novel targets and therapeutic drugs for chronic inflammatory diseases.
In Volume I, many manuscripts were submitted and reviewed. Scopes of accepted manuscripts involved in ALI, allergic rhinitis, asthma, liver injury, gouty arthritis, and cancer et al. These studies provide a fundamental understanding of the pathogenesis and therapeutic targets of chronic inflammatory diseases, which can be very useful for clinical treatment. Following Volume I, the aim of this Research Topic is to investigate the pathogenesis and pathophysiology of chronic inflammatory diseases, clarify the role of inflammatory and immune responses, and focus on therapeutic drugs and natural compounds to discover new therapeutic agents and clinical drugs of therapy chronic inflammatory diseases. Through combing clinical data with basic function research of chronic inflammatory diseases, potential new drug targets could be discovered for chronic inflammatory diseases. Therefore, this topic aims to include a study of pathological mechanisms, the evaluation of therapeutic drugs, the screening of new drugs based on new targets, and the construction of novel drug delivery systems, early diagnosis, drug development, and the study of sequencing tools.
In this Research Topic, we welcome original research articles, reviews, opinion, perspective, and systematic review, including but not limited to the following themes:
• Research on the pathophysiological mechanisms and novel targets in chronic inflammatory diseases.
• Research on the role of inflammatory and immune responses and the pathophysiological mechanisms.
• Elucidation of mechanisms for therapeutic drugs in chronic inflammatory diseases.
• Discovery of new therapeutic drugs and natural compounds for the treatment of chronic inflammatory diseases.
• Research on drug transformation and druggability of chronic inflammatory diseases.
Please note: only manuscripts reporting on chemically defined compounds (no plant extracts etc.) are accepted.