Aberrant metabolism and altered gene expression patterns have been observed in solid tumors, leading to altered cellular signaling pathways and increased resistance to radiotherapy and immunotherapy. Studies have shown that the metabolic reprogramming contributes to tumor progression and resistance to treatment, such as the classic Warburg effect, which allows for rapid energy production and growth. Local metabolism reprogramming, hypoxia, and lactate enrichment could cause the dysregulation of immune related genes, such as PD-L1 and CTLA-4, and immune cells, such as CTLs, tumor-associated macrophages and regulatory T cells, contributing to immunotherapy resistance in solid tumors. Moreover, evidence has shown that the radiotherapy response could elevate due to the activation of cGAS-STING pathways, influenced by altered local metabolism pattern. Overall, the dysregulation of metabolism and associated genes plays a critical role in solid tumor initiation, development, and resistance to radiotherapy and immunotherapy. Understanding these mechanisms can aid in developing more effective therapies for these types of cancer.
Metabolic reprogramming has been part of the hallmarks of tumors, consequently, the dysregulation of metabolism and associated genes in tumors have been extensively explored. Given the evidence that local metabolism dysregulation certainly affects the function of immunocytes and the competence of cell damage repair and reproduction, novel therapeutic target identification and treatment strategy optimization are urgently needed. Our understanding of the dysregulated metabolism and associated genes and its clinical significance in tumors would deepen the cognition of tumor development related mechanisms and improve the efficacy of treatment response.
This Research Topic focuses on the latest advances in the dysregulation of metabolism and associated genes in the development of solid tumors and resistance to treatments. We welcome submissions of Original Research, Brief Research Reports, Reviews, Mini-reviews, Methods, Perspectives and Opinion articles focusing on, but not limited to, the following topics:
• The impact of changes in metabolism on immunotherapy and/or radiotherapy to solid tumors;
• The role of dysregulated metabolism and associated genes in tumor initiation and development;
• The mutual influences of immunotherapy/radiotherapy side effects and the metabolism;
• The mechanism of metabolism alteration in tumor immune escape and how to employ microbes to treat immune escape;
• The characteristics and mechanisms of the metabolism landscape under combined immunotherapy and radiotherapy;
• The role of metabolism reprogramming caused by dysregulation of associated genes in solid tumor resistance to immunotherapy/radiotherapy.
Aberrant metabolism and altered gene expression patterns have been observed in solid tumors, leading to altered cellular signaling pathways and increased resistance to radiotherapy and immunotherapy. Studies have shown that the metabolic reprogramming contributes to tumor progression and resistance to treatment, such as the classic Warburg effect, which allows for rapid energy production and growth. Local metabolism reprogramming, hypoxia, and lactate enrichment could cause the dysregulation of immune related genes, such as PD-L1 and CTLA-4, and immune cells, such as CTLs, tumor-associated macrophages and regulatory T cells, contributing to immunotherapy resistance in solid tumors. Moreover, evidence has shown that the radiotherapy response could elevate due to the activation of cGAS-STING pathways, influenced by altered local metabolism pattern. Overall, the dysregulation of metabolism and associated genes plays a critical role in solid tumor initiation, development, and resistance to radiotherapy and immunotherapy. Understanding these mechanisms can aid in developing more effective therapies for these types of cancer.
Metabolic reprogramming has been part of the hallmarks of tumors, consequently, the dysregulation of metabolism and associated genes in tumors have been extensively explored. Given the evidence that local metabolism dysregulation certainly affects the function of immunocytes and the competence of cell damage repair and reproduction, novel therapeutic target identification and treatment strategy optimization are urgently needed. Our understanding of the dysregulated metabolism and associated genes and its clinical significance in tumors would deepen the cognition of tumor development related mechanisms and improve the efficacy of treatment response.
This Research Topic focuses on the latest advances in the dysregulation of metabolism and associated genes in the development of solid tumors and resistance to treatments. We welcome submissions of Original Research, Brief Research Reports, Reviews, Mini-reviews, Methods, Perspectives and Opinion articles focusing on, but not limited to, the following topics:
• The impact of changes in metabolism on immunotherapy and/or radiotherapy to solid tumors;
• The role of dysregulated metabolism and associated genes in tumor initiation and development;
• The mutual influences of immunotherapy/radiotherapy side effects and the metabolism;
• The mechanism of metabolism alteration in tumor immune escape and how to employ microbes to treat immune escape;
• The characteristics and mechanisms of the metabolism landscape under combined immunotherapy and radiotherapy;
• The role of metabolism reprogramming caused by dysregulation of associated genes in solid tumor resistance to immunotherapy/radiotherapy.